Recently, a number of genome-wide affiliation research recognized PHACTR1 as key locus for 5 numerous vascular issues: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these signify important threat components or comorbidities for ischemic stroke, PHACTR1 function in mind small vessel ischemic disease and ischemic stroke most vital survival mechanism, such because the recruitment of mind collateral arteries like posterior speaking arteries (PcomAs), stays unknown.
Therefore, we utilized exome and genome sequencing in a multi-ethnic cohort of 180 early-onset unbiased familial and apparently sporadic mind small vessel ischemic disease and CADASIL-like Caucasian patients from US, Portugal, Finland, Serbia and Turkey and in 2 C57BL/6J stroke mouse fashions (bilateral widespread carotid artery stenosis [BCCAS] and center cerebral artery occlusion [MCAO]), characterised by totally different levels of PcomAs patency. We report three very uncommon coding variants in the small vessel ischemic disease-CADASIL-like cohort (p.Glu198Gln, p.Arg204Gly, p.Val251Leu) and a stop-gain mutation (p.Gln273*) in one MCAO mouse.
These coding variants do not cluster in PHACTR1 identified pathogenic domains and are not prone to play a critical function in small vessel ischemic disease or mind collateral circulation. We additionally exclude the chance that replicate quantity variants (CNVs) or a variant enrichment in Phactr1 could also be related to PcomA recruitment in BCCAS mice or linked to numerous vascular traits (cerebral blood move pre-surgery, PcomA measurement, leptomeningeal microcollateral size and junction density throughout mind hypoperfusion) in C57BL/6J mice, respectively.
Genetic variability in PHACTR1 is not prone to be a standard susceptibility issue influencing small vessel ischemic disease in patients and PcomA recruitment in C57BL/6J mice. Nonetheless, uncommon variants in PHACTR1 RPEL domains could affect the stroke final result and are price investigating in a bigger cohort of small vessel ischemic disease patients, totally different ischemic stroke subtypes and with purposeful research.
Insight of fetal to grownup hemoglobin change: Genetic modulators and therapeutic targets
The medical heterogeneity of β-hemoglobinopathies is so variable that it prompted the researchers to determine the genetic modulators of those ailments. Though the first modulator is the kind of β-globin mutation which impacts the diploma of β-globin chain synthesis, the co-inheritance of α-thalassemia and the fetal hemoglobin (HbF) ranges additionally act as potent secondary genetic modifiers.
As elevated HbF ranges ameliorate the severity of hemoglobinopathies, in this evaluate, the genetic modulators mendacity inside and outdoors the β-globin gene cluster with their believable function in governing the HbF ranges have been summarised, which in future could act as potential therapeutic targets.
Genetic affiliation of MMP14 promoter variants and their purposeful significance in gallbladder most cancers pathogenesis
Gallbladder most cancers (GBC) is comparatively uncommon however exhibits excessive frequency in sure geographical areas and ethnic teams, which embrace Northern and Eastern states of India. Previous research in India have indicated the doable function of genetic predisposition in GBC pathogenesis. Although matrix metalloproteinase-14 (MMP14) is identified modulator of tumour microenvironment and tumorigenesis and TCGA information additionally suggests its upregulation but, its function in genetic predisposition for GBC is utterly unknown.
We explored MMP14 promoter genetic variants as threat components and their implication in expression modulation and the pathogenesis of GBC. We genotyped all single nucleotide polymorphisms of MMP14 promoter by Sanger’s sequencing in roughly 300 GBC and 300 management examine topics of Indian ethnicity and, in 26 GBC tissue samples. Protein expression of MMP14 in GBC tissue samples was checked by immunohistochemistry. In vitro luciferase reporter assay was carried out to elucidate function of promoter genetic variants on expression ranges in two totally different cell traces.
MMP14 promoter variants, rs1003349 (p worth = 0.0008) and rs1004030 (p worth = 0.0001) have been considerably related to GBC. Luciferase reporter assay confirmed excessive expression for threat alleles of each the SNPs. Genotype-phenotype correlation for rs1003349 and rs1004030, in affected person pattern, confirmed that threat allele carriers had increased expression ranges of MMP14; furthermore, the correlation sample matched with genetic affiliation fashions. Overall, this examine unravels the affiliation of MMP14 promoter SNPs with GBC which contribute to pathogenesis by rising its expression.
Compact Genetic Algorithm-based Feature Selection for Sequence-based Prediction of Dengue-Human Protein Interactions
Dengue Virus (DENV) an infection is one of many quickly spreading mosquito-borne viral infections in people. Every yr, round 50 million folks get affected by DENV an infection, ensuing in 20,000 deaths. Despite the latest experiments specializing in dengue an infection to know its performance in the human physique, a number of functionally vital DENV-human protein-protein interactions (PPIs) have remained unrecognized. This article presents a mannequin for predicting new DENV-human PPIs by combining totally different sequence-based options of human and dengue proteins just like the amino acid composition, dipeptide composition, conjoint triad, pseudo amino acid composition, and pairwise sequence similarity between dengue and human proteins.
A Learning vector quantization (LVQ)-based Compact Genetic Algorithm (CGA) mannequin is proposed for characteristic subset choice. CGA is a probabilistic approach that simulates the habits of a Genetic Algorithm (GA) with lesser reminiscence and time necessities. Prediction of DENV-human PPIs is carried out by the weighted Random Forest approach because it is discovered to carry out higher than different classifiers. We have predicted 1013 PPIs between 335 human proteins and 10 dengue proteins.
 5-50UL 8-CHANNEL, DIGITAL PIPETTOR |
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| AP-8-50 | CORNING | 1/pk | EUR 425 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 DiscoveryPak™ Antiviral Agents Set |
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| S252-8 | Biovision | 8 antiviral agents | EUR 839 |
 ECM antibody |
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| 70R-12136 | Fitzgerald | 100 ug | EUR 403 |
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Description: Rabbit polyclonal ECM antibody |
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 ECM Antibody |
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| 3843-100 | Biovision | EUR 316 | |
ECM Antibody |
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| 3843-30T | Biovision | EUR 146 | |
 1730 8 SNAP-SEAL 8 OZ |
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| 1730-8 | CORNING | 100/pk | EUR 74 |
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Description: Disposable Plastic; Plastic Containers |
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 Optional eight channel adapter |
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| V1002-8 | BenchMark | 1 PC | EUR 236.39 |
 AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4 |
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| AP-8-10-ALT | CORNING | 1/pk | EUR 456 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10 |
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| AP-8-10-STD | CORNING | 1/pk | EUR 507 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4 |
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| AP-8-200-ALT | CORNING | 1/pk | EUR 456 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10 |
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| AP-8-200-STD | CORNING | 1/pk | EUR 507 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4 |
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| AP-8-300-ALT | CORNING | 1/pk | EUR 456 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10 |
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| AP-8-300-STD | CORNING | 1/pk | EUR 507 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4 |
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| AP-8-50-ALT | CORNING | 1/pk | EUR 456 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10 |
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| AP-8-50-STD | CORNING | 1/pk | EUR 507 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 ECM Blocking Peptide |
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| 33R-10952 | Fitzgerald | 50 ug | EUR 191 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ECM antibody, catalog no. 70R-12136 |
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ECM Blocking Peptide |
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| 3843BP-50 | Biovision | EUR 153 | |
 Polyclonal ECM Antibody |
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| APR00211G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ECM . This antibody is tested and proven to work in the following applications: |
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 Individual Reaction Mix 8 |
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| G065-8 | ABM | 200 reactions | EUR 167 |
 Human IL-8 Recombinant Protein |
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| R00423-8 | BosterBio | 5ug/vial | EUR 259 |
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Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast. |
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 AXYGEN® AXYPET® PRO 0.5-10 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE |
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| AP-8-10-P | CORNING | 1/pk | EUR 455 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYGEN® AXYPET® PRO 20-200 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE |
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| AP-8-200-P | CORNING | 1/pk | EUR 455 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYGEN® AXYPET® PRO 30-300 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE |
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| AP-8-300-P | CORNING | 1/pk | EUR 455 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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 AXYGEN® AXYPET® PRO 5-50 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE |
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| AP-8-50-P | CORNING | 1/pk | EUR 455 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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, Colorimetric) CytoSelect 24-well Cell Migration Assay (8 ?m), Colorimetric |
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| CBA-100 | Cell Biolabs | 12 assays | EUR 543 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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CytoSelect 24-well Cell Migration Assay (8 ?m), Colorimetric |
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| CBA-100-5 | Cell Biolabs | 5 x 12 assays | EUR 2288 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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, Fluorometric) CytoSelect 24-well Cell Migration Assay (8 ?m), Fluorometric |
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| CBA-101 | Cell Biolabs | 12 assays | EUR 554 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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CytoSelect 24-well Cell Migration Assay (8 ?m), Fluorometric |
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| CBA-101-5 | Cell Biolabs | 5 x 12 assays | EUR 2323 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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, Fluorometric) CytoSelect 96-well Cell Migration Assay (8 ?m), Fluorometric |
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| CBA-106 | Cell Biolabs | 96 assays | EUR 635 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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CytoSelect 96-well Cell Migration Assay (8 ?m), Fluorometric |
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| CBA-106-5 | Cell Biolabs | 5 x 96 assays | EUR 2613 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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) WB ECM kit (Mouse IgG) |
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| LF-QC5001 | Abfrontier | 1 kit | EUR 253 |
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Description: Our Enhanced Chemiluminescent Kit is an easy, consistent, sensitive and highly specific detection solution to your protein of interest. Powered by our proprietary and easy to use substrates, a unique blocking agent, highly specific secondary antibodies, and carefully optimized protocols, this kit offers the highest signal to noise ratio available and yields clean results, blot after blot. |
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) WB ECM kit (Rabbit IgG) |
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| LF-QC5002 | Abfrontier | 1 kit | EUR 253 |
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Description: Our Enhanced Chemiluminescent Kit is an easy, consistent, sensitive and highly specific detection solution to your protein of interest. Powered by our proprietary and easy to use substrates, a unique blocking agent, highly specific secondary antibodies, and carefully optimized protocols, this kit offers the highest signal to noise ratio available and yields clean results, blot after blot. |
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) WB ECM kit (Goat IgG) |
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| LF-QC5003 | Abfrontier | 1 kit | EUR 253 |
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Description: Our Enhanced Chemiluminescent Kit is an easy, consistent, sensitive and highly specific detection solution to your protein of interest. Powered by our proprietary and easy to use substrates, a unique blocking agent, highly specific secondary antibodies, and carefully optimized protocols, this kit offers the highest signal to noise ratio available and yields clean results, blot after blot. |
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) WB ECM kit (Rat IgG) |
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| LF-QC5004 | Abfrontier | 1 kit | EUR 253 |
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Description: Our Enhanced Chemiluminescent Kit is an easy, consistent, sensitive and highly specific detection solution to your protein of interest. Powered by our proprietary and easy to use substrates, a unique blocking agent, highly specific secondary antibodies, and carefully optimized protocols, this kit offers the highest signal to noise ratio available and yields clean results, blot after blot. |
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) WB ECM kit (Mouse IgM) |
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| LF-QC5005 | Abfrontier | 1 kit | EUR 253 |
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Description: Our Enhanced Chemiluminescent Kit is an easy, consistent, sensitive and highly specific detection solution to your protein of interest. Powered by our proprietary and easy to use substrates, a unique blocking agent, highly specific secondary antibodies, and carefully optimized protocols, this kit offers the highest signal to noise ratio available and yields clean results, blot after blot. |
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 ELISA Kit) 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| DLR-8-OHdG-Ge-48T | DL Develop | 48T | EUR 469 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids. |
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8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| DLR-8-OHdG-Ge-96T | DL Develop | 96T | EUR 608 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids. |
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 ELISA Kit) General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| RD-8-OHdG-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 467 |
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| RD-8-OHdG-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 646 |
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| RDR-8-OHdG-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 488 |
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit |
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| RDR-8-OHdG-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 676 |
 pAAV-DJ/8 Vector |
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| VPK-420-DJ-8 | Cell Biolabs | 10 µg | EUR 647 |
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Description: The pAAV-DJ/8 vector contains the rep and cap genes required to generated recombinant AAV of serotype DJ/8. Co-transfect with other packaging plasmids and an expression vector into 293 cells for AAV-DJ/8 packaging. |
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 CytoSelect Leukocyte Transmigration Assay |
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| CBA-212 | Cell Biolabs | 24 assays | EUR 740 |
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Description: Cancer cell transmigration, particularly extravasation, is an important step in cancer metastasis. It is the final step in a cascade of interactions between cells and the endothelium. CytoSelect Leukocyte Transmigration Assay provides a robust system for the quantitative determination of transmigrations and interactions between endothelium and leukocytes. Migratory cells may be quantified on a fluorescence plate reader. Kits use 24-well plates with 3 µm pore size membrane inserts. |
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, COL-coated, Colorimetric) CytoSelect 24-well Cell Haptotaxis Assay (8 µm), COL-coated, Colorimetric |
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| CBA-100-COL | Cell Biolabs | 12 assays | EUR 566 |
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Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells. |
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, FN-coated, Colorimetric) CytoSelect 24-well Cell Haptotaxis Assay (8 µm), FN-coated, Colorimetric |
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| CBA-100-FN | Cell Biolabs | 12 assays | EUR 566 |
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Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells. |
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, COL-coated, Fluorometric) CytoSelect 24-well Cell Haptotaxis Assay (8 µm), COL-coated, Fluorometric |
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| CBA-101-COL | Cell Biolabs | 12 assays | EUR 595 |
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Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells. |
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, FN-coated, Fluorometric) CytoSelect 24-well Cell Haptotaxis Assay (8 µm), FN-coated, Fluorometric |
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| CBA-101-FN | Cell Biolabs | 12 assays | EUR 595 |
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Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells. |
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 Antibody) Transmembrane Channel Like 8 (TMC8) Antibody |
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| 20-abx219015 | Abbexa |
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Transmembrane Channel Like 8 (TMC8) Antibody |
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| 20-abx329114 | Abbexa |
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Transmembrane Channel Like 8 (TMC8) Antibody |
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| abx027907-400ul | Abbexa | 400 ul | EUR 523 |
Transmembrane Channel Like 8 (TMC8) Antibody |
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| abx027907-80l | Abbexa | 80 µl | EUR 286 |
 EmbryoFix™ |
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| PF102 | FD Neurotechnologies | 20 ml | EUR 55 |
 MycoRid™ |
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| M093-10ML | TOKU-E | 10mL | EUR 101 |
MycoRid™ |
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| M093-1ML | TOKU-E | 1mL | EUR 30 |
MycoRid™ |
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| M093-5x10ML | TOKU-E | 5x10mL | EUR 340 |
MycoRid™ |
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| M093-5x1ML | TOKU-E | 5x1mL | EUR 74 |
 BindPro™ |
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| BP355-15 | Biotech Support Group | 15mL | EUR 481 |
BindPro™ |
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| BP355-50 | Biotech Support Group | 50mL | EUR 806 |
 HemogloBind™ |
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| H0145-05 | Biotech Support Group | 5 mL | EUR 359 |
|
Description: Hemoglobin Removal Kit |
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HemogloBind™ |
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| H0145-15 | Biotech Support Group | 15 mL | EUR 709 |
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Description: Hemoglobin Removal Kit |
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HemogloBind™ |
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| H0145-50 | Biotech Support Group | 50 mL | EUR 1420 |
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Description: Hemoglobin Removal Kit |
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 ProCipitate™ |
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| P0050-100 | Biotech Support Group | 100 mL | EUR 1217 |
|
Description: DNA/RNA Enrichment Kit |
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ProCipitate™ |
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| P0050-30 | Biotech Support Group | 30 mL | EUR 511 |
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Description: DNA/RNA Enrichment Kit |
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 Viraffinity™ |
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| V1062-15 | Biotech Support Group | 15 mL | EUR 501 |
 Cleanascite™ |
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| X2555-10 | Biotech Support Group | 10 mL | EUR 405 |
|
Description: Lipid Removal Reagent |
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Cleanascite™ |
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| X2555-100 | Biotech Support Group | 100 mL | EUR 704 |
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Description: Lipid Removal Reagent |
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Cleanascite™ |
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| X2555-1000 | Biotech Support Group | 1 Liter | Ask for price |
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Description: Lipid Removal Reagent |
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Cleanascite™ |
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| X2555-50 | Biotech Support Group | 50 mL | EUR 521 |
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Description: Lipid Removal Reagent |
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, Trial Size) CytoSelect 24-Well Cell Migration Assay (8 µm, Colorimetric Format), Trial Size |
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| CBA-100-T | Cell Biolabs | 4 assays | EUR 299 |
|
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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, Trial Size) CytoSelect 24-Well Cell Migration Assay (8 µm, Fluorometric Format), Trial Size |
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| CBA-101-T | Cell Biolabs | 4 assays | EUR 299 |
|
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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 ELISA test) PSA (Prostate-specific antigen) ELISA test |
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| 8 | Biobase | 96T/Box | Ask for price |
|
Description: ELISA based test for quantitative detection of PSA (Prostate-specific antigen) |
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 CytoSelect Tumor-endothelium Adhesion Assay |
|||
| CBA-215 | Cell Biolabs | 100 assays | EUR 577 |
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Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Tumor Endothelium Adhesion Assay provides a robust system for the quantitative determination of interactions between tumor cells and endothelium. Adherent cells can be easily quantified on a fluorescence plate reader. |
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 CytoSelect Tumor Transendothelial Migration Assay |
|||
| CBA-216 | Cell Biolabs | 24 assays | EUR 740 |
|
Description: Cancer cell transmigration, particularly extravasation, is an important step in cancer metastasis. It is the final step in a cascade of interactions between cells and the endothelium. CytoSelect Tumor Transendothelial Migration Assay provides a robust system for the quantitative determination of transmigrations and interactions between endothelium and tumor cells. Migratory cells may be quantified on a fluorescence plate reader. Kits use 24-well plates with 8 µm pore size membrane inserts. |
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 CytoSelect LDH Cytotoxicity Assay Kit |
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| CBA-241 | Cell Biolabs | 960 assays | EUR 403 |
|
Description: Cell Biolabs? CytoSelect LDH Cytotoxicity Assay Kit provides a colorimetric format for measuring and monitoring cell cytotoxicity. The kit contains sufficient reagents for the evaluation of 960 assays in 96-well plates. Cells can be plated and then treated with compounds or agents that affect cell viability. Upon cell death, lactate dehydrogenase (LDH), a soluble enzyme found in the cytoplasm, is released into the growth media. The growth media is then transferred to another plate and the released LDH is then detected with cytotoxicity reagent. In the presence of lactate substrate (included in the LDH Cytotoxicity Reagent) LDH converts lactate to pyruvate and generates nicotinamide adenine dinucleotide (NADH). The WST-1 molecule, also present in the LDH Cytotoxicity Reagent, is converted from WST-1 to the orange formazan form. An increase in cell cytotoxicity is accompanied by increased LDH release and increased colorimetric signal. The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues, depending on LDH expression levels. The LDH Cytotoxicity Reagent can be used to detect cytotoxicity in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells. |
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 CytoSelect MTT Cell Proliferation Assay |
|||
| CBA-252 | Cell Biolabs | 960 assays | EUR 409 |
|
Description: Cell Biolabs? CytoSelect MTT Cell Proliferation Assay provides a colorimetric format for measuring and monitoring cell proliferation. The kit contains sufficient reagents for the evaluation of 960 assays in 96-well plates or 192 assays in 24-well plates. Cells can be plated and then treated with compounds or agents that affect proliferation. Cells are then detected with the proliferation reagent, which is converted in live cells from the yellow tetrazole MTT to the purple formazan form by a cellular reductase (Figure 1). An increase in cell proliferation is accompanied by an increased signal, while a decrease in cell proliferation (and signal) can indicate the toxic effects of compounds or suboptimal culture conditions. The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues. This cell proliferation reagent can be used to detect proliferation in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells. |
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 CytoSelect BrdU Competitive ELISA Kit |
|||
| CBA-5098 | Cell Biolabs | 96 assays | EUR 543 |
 CytoSelect IdU Competitive ELISA Kit |
|||
| CBA-5100 | Cell Biolabs | 96 assays | EUR 543 |
 CytoSelect EdU Competitive ELISA Kit |
|||
| CBA-5101 | Cell Biolabs | 96 assays | EUR 543 |
 ASPIR-8, 5ml reservoir for 8-channel pipettes, individually wrapped |
|||
| P7005-1S | MTC Bio | 100/pack | EUR 99.95 |
|
Description: ASPIR-8 5ml reservoir for 8-channel pipettes |
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 ASPIR-8, 25ml reservoir for 8-channel pipettes, individually wrapped |
|||
| P7025-1S | MTC Bio | 100/pack | EUR 99.95 |
|
Description: ASPIR-8 25ml reservoir for 8-channel pipettes |
|||
 ASPIR-8, 10ml reservoir for 8-channel pipettes, individually wrapped |
|||
| P8010-1S | MTC Bio | 100/pack | EUR 99.95 |
|
Description: ASPIR-8 10ml reservoir for 8-channel pipettes |
|||
 AAV-DJ/8 Helper Free Packaging System |
|||
| VPK-400-DJ-8 | Cell Biolabs | 1 kit | EUR 972 |
|
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
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 AAV-DJ/8 Helper Free Expression System |
|||
| VPK-410-DJ-8 | Cell Biolabs | 1 kit | EUR 1239 |
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Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues. |
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 scAAV-DJ/8 Helper Free Expression System |
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| VPK-430-DJ-8 | Cell Biolabs | 1 kit | EUR 1239 |
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Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues. |
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, Colorimetric, Combo Kit) CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Colorimetric, Combo Kit |
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| CBA-100-C | Cell Biolabs | 2 x 12 assays | EUR 972 |
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Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays. |
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CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Colorimetric, Combo Kit |
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| CBA-100-C-5 | Cell Biolabs | 10 x 12 assays | EUR 3976 |
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Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays. |
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, Fluorometric, Combo Kit) CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Fluorometric, Combo Kit |
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| CBA-101-C | Cell Biolabs | 2 x 12 assays | EUR 972 |
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Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays. |
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, Fluorometric, Combo Kit) CytoSelect 96-well Cell Migration and Invasion Assay (8 µm), Fluorometric, Combo Kit |
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| CBA-106-C | Cell Biolabs | 2 x 96 assays | EUR 1146 |
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Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 96-well combo kit provides sufficient reagents to perform 96 cell migration plus 96 cell invasion assays. |
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 PIPETTOR,8 CHANNEL,20-200UL,1 EA |
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| 4888 | CORNING | 1/pk | EUR 849 |
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Description: Corning Liquid Handling Equipment; Costar 8 Pette and 12 Pette Multichannel Pipettors |
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 replacement) ELISA Microplate Washer Head (8 channel) replacement |
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| MPW-WH-1 | Alpha Diagnostics | 1 | EUR 354 |
 AAV-DJ/8 Helper Free Promoterless Expression System |
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| VPK-411-DJ-8 | Cell Biolabs | 1 kit | EUR 1239 |
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Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues. |
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 ASPIR-8, 5ml reservoir for 8-channel pipettes, 5/sterile bag |
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| P7005-5S | MTC Bio | 200/pack | EUR 116.15 |
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Description: ASPIR-8 5ml reservoir for 8-channel pipettes |
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All predicted interactions are validated by literature filtering, GO-based evaluation, and KEGG Pathway enrichment evaluation. This examine will encourage the identification of potential targets for simpler anti-dengue drug discovery.